Tiobe-2010年9月份编程语言排行榜发布了，面对C语言的强力冲击Java仍然屹立在编程语言的头把交椅上。而C语言再次跻身第第二同时也保持了快速上升的势头。而第三名则被C++继续蝉联，之前一直跻身前三甲的PHP则名列第四。同时本次TIOBE-2010年9月份编程语言排行榜对做了两项重大的改变，可能也是本期编程榜姗姗来迟的主要原因。第一个是关于语言的分组，新榜单中Lisp、Scheme、Clojure不再被分在一组；另一个则是忽略了Yahoo!的搜索结果。
| Position Sep 2010 | Position Sep 2009 | Delta in Position | Programming Language | Ratings Sep 2010 | Delta Sep 2009 | Status |
|---|---|---|---|---|---|---|
| 1 | 1 |  | Java | 17.915% | -1.47% | A |
| 2 | 2 | | C | 17.147% | +0.29% | A |
| 3 | 4 |  | C++ | 9.812% | -0.18% | A |
| 4 | 3 |  | PHP | 8.370% | -1.79% | A |
| 5 | 5 | | (Visual) Basic | 5.797% | -3.40% | A |
| 6 | 7 | | C# | 5.016% | +0.83% | A |
| 7 | 8 | | Python | 4.583% | +0.65% | A |
| 8 | 18 | | Objective-C | 3.368% | +2.78% | A |
| 9 | 6 | | Perl | 2.447% | -2.08% | A |
| 10 | 10 | | Ruby | 1.907% | -0.47% | A |
| 11 | 9 | | JavaScript | 1.665% | -1.33% | A |
| 12 | 11 | | Delphi | 1.585% | -0.39% | A |
| 13 | 13 | | Lisp | 1.084% | +0.24% | A– |
| 14 | 12 | | Pascal | 0.790% | -0.17% | A– |
| 15 | 27 | | Transact-SQL | 0.771% | +0.40% | A– |
| 16 | – | | Go | 0.728% | +0.73% | A– |
| 17 | 21 | | RPG (OS/400) | 0.715% | +0.26% | A– |
| 18 | 30 | | PowerShell | 0.686% | +0.42% | B |
| 19 | 24 | | Ada | 0.676% | +0.29% | B |
| 20 | 14 | | PL/SQL | 0.637% | -0.18% | A- |